Estrogens, androgens and generalized behavioral arousal in gonadectomized female and male C57BL/6 mice

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Androgens play a number of important physiological roles in the human. In the male, testosterone is required for virilization, normal sexual function, and both stimulation and maintenance of bone and muscle mass. Epidemiological studies have shown a progressive decline in testosterone levels with ageing in men. The clinical significance of this decline is still unclear, and there is controversy...

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The effects of injected estrogenic and androgenic preparations on the weights of various organs in normal and castrated rats have been studied extensively.3' A pronounced increase in renal weight followed some of the hormonal treatments employed. However, no information was given concerning the nature of the relative renal hypertrophy, since only weight changes were reported. In this laboratory...

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Androgens and estrogens in skeletal sexual dimorphism

Bone is an endocrine tissue expressing androgen and estrogen receptors as well as steroid metabolizing enzymes. The bioactivity of circulating sex steroids is modulated by sex hormone-binding globulin and local conversion in bone tissue, for example, from testosterone (T) to estradiol (E2) by aromatase, or to dihydrotestosterone by 5α-reductase enzymes. Our understanding of the structural basis...

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ژورنال

عنوان ژورنال: Physiology & Behavior

سال: 2015

ISSN: 0031-9384

DOI: 10.1016/j.physbeh.2015.04.053